Rapid Screening of Submicroliter Urine Samples for Drugs of Abuse utilizing Pulsed Gas Ambient Ionization
Rapid detection of trace drugs-of-abuse in urine is demonstrated using a pulsed gas direct analysis in real time ambient ionization equipped time-of-flight mass spectrometer. Submicroliter sampling combined with analysis at multiple temperatures serve to minimize the matrix effects normally encountered in direct analysis of urine without pre-processing to remove salts, proteins, metabolic products including creatinine and urea.