Using ASAP-MS to detect the difference between over-the-counter and counterfeit paracetamol tablets
Gas chromatography coupled with mass spectrometry (GC-MS) or high-resolution mass spectrometry (GCxGC-HRMS) is widely used to identify differences between similar samples. Comprehensive two-dimensional gas chromatography combined with high-resolution mass spectrometry (GCxGC-HRMS) uses two columns with different phases to achieve greater separation of complex mixtures. Each separation method has its strengths and weaknesses with respect to hardware setup and information content.