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The ACQUITY™ RDa™ Detector Combined With RemoteAnalyzer® Software to Give Simple, Rapid Accurate Mass Information in a Walk-Up Environment
Chris Henrya, Paul D. Rainvillea and Scott J. Campbellb
aWaters Corporation, Wilmslow, UK, bSpectralWorks Ltd, Runcorn, UK.
A Waters application note
Abstract
The rapid detection of illicit materials (e.g. narcotics or energetic substances) at social gatherings (festivals) transport locations (airports etc) and border entry points is gaining increasing interest as a means to enhance security and ensure public safety. Rapid analysis of such samples is now possible with the improvement of ambient ionization techniques (in this case a novel thermal desorption ionization source) and a compact, deployable Mass Spectrometric system. This study demonstrates the capability of such a system to perform real-time targeted library matching, delivering results in under 20 seconds.
Benefits
- Routine access to accurate mass measurements for mass confirmation of API (Active Pharmaceutical Ingredient) and related impurities for synthetic chemists.
- Fast scanning rate of the RDa Tof (Time-of-Flight) detector enabling rapid UPLC™ gradients without compromising qualitative data.
- Rapid results via email for convenient, timely decision making on reaction outcomes.
- Flexible RemoteAnalyzer software can be configured to have specific access as role requires
Introduction
Many organic chemists employ mass spectrometry (MS) as a convenient verification tool for their product, and any impurities present in a synthetic reaction.
Single quadrupole mass spectrometers provide only nominal mass data which while useful, does not eliminate the potential of mis-assignment of the target compound, degradants, impurities, or side reaction products. Increased confidence through compound characterization is possible through the accurate mass measurements provided by ToF high resolution mass spectrometry (HRMS) which can require high levels of expertise to operate.
The ACQUITY RDa Detector with its simple, automatic setup was designed to make accurate mass measurements more accessible for a wider range of chemists.
The intuitive ‘point and click’ browser based RemoteAnalyzer software further simplifies sample submission for both single and batch analyses.
To highlight the benefits of this approach, ramipril 2-[N-[(S)-1-Ethoxycarbonyl-3-phenylpropyl]-Lalanyl]-(1S, 3S, 5S)-2-azabicyclo[3.3.0]octane-3-carboxylic acid (CAS no. 87333-19-5), an angiotensin-converting enzyme (ACE) inhibitor was spiked at 0.1% (w/w) with four related impurities; ramipril isopropyl ester, ramipril diketopiperazine, ramipril methyl ester and hexahydroramipril labelled A-D respectively and analyzed using the ACQUITY RDa.
(ACE) inhibitors constitute an important class of therapeutic agents for the regulation of hypertension.
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